{"id":23386,"date":"2014-04-17T07:28:37","date_gmt":"2014-04-17T07:28:37","guid":{"rendered":"http:\/\/chanhkien.org\/?p=23386"},"modified":"2014-11-18T05:10:05","modified_gmt":"2014-11-18T05:10:05","slug":"tu-luyen-mot-lieu-phap-gen-moi-vo-cung-hieu-qua","status":"publish","type":"post","link":"https:\/\/chanhkien.org\/2014\/04\/tu-luyen-mot-lieu-phap-gen-moi-vo-cung-hieu-qua.html","title":{"rendered":"Tu luy\u1ec7n: M\u1ed9t li\u1ec7u ph\u00e1p gen m\u1edbi v\u00f4 c\u00f9ng hi\u1ec7u qu\u1ea3"},"content":{"rendered":"<p><b>[Chanhkien.org]<\/b> Ng&agrave;y nay, nghi&ecirc;n c&#7913;u y h&#7885;c quy k&#7871;t nguy&ecirc;n nh&acirc;n g&acirc;y ra nhi&#7873;u c&#259;n b&#7879;nh c&#7911;a con ng&#432;&#7901;i l&agrave; do &#273;&#7897;t bi&#7871;n gen c&#7911;a t&#7871; b&agrave;o. Nhi&#7873;u khoa h&#7885;c gia v&agrave; b&aacute;c s&#297; &#273;ang n&#7895; l&#7921;c nh&#7857;m t&igrave;m ra c&aacute;c ph&#432;&#417;ng th&#7913;c &#273;&#7863;c th&ugrave; &#273;&#7875; &#273;i&#7873;u ch&#7881;nh l&#7841;i nh&#7919;ng gen b&#7883; x&aacute;o tr&#7897;n n&agrave;y. Tuy nhi&ecirc;n, v&#7845;n &#273;&#7873; &#7903; &#273;&acirc;y kh&ocirc;ng ph&#7843;i ch&#7881; l&agrave; m&#7897;t v&agrave;i t&#7871; b&agrave;o trong c&#417; th&#7875;, m&agrave; th&#7853;t ra c&ograve;n c&oacute; r&#7845;t r&#7845;t nhi&#7873;u t&#7871; b&agrave;o. Do &#273;&oacute;, c&#7843;i ch&iacute;nh l&#7841;i nh&#7919;ng gen b&#7883; &#273;&#7897;t bi&#7871;n trong c&#417; th&#7875; ng&#432;&#7901;i kh&ocirc;ng ph&#7843;i l&agrave; vi&#7879;c d&#7877; d&agrave;ng. B&#7903;i v&igrave; c&aacute;c t&#7871; b&agrave;o b&igrave;nh th&#432;&#7901;ng l&#7851;n b&#7845;t th&#432;&#7901;ng &#273;&#7873;u c&ugrave;ng sinh ra t&#7915; m&#7897;t ngu&#7891;n trong c&#417; th&#7875; b&#7879;nh nh&acirc;n, r&#7845;t kh&oacute; ph&acirc;n bi&#7879;t &#273;&#432;&#7907;c ch&uacute;ng. M&#7863;c d&ugrave; c&aacute;c nh&agrave; khoa h&#7885;c &#273;&atilde; c&#7889; g&#7855;ng d&ugrave;ng c&aacute;c lo&#7841;i virus, kh&aacute;ng th&#7875; ho&#7863;c nh&#7919;ng c&aacute;ch th&#7913;c kh&aacute;c &#273;&#7875; nh&#7853;n di&#7879;n c&aacute;c protein m&#7909;c ti&ecirc;u trong nh&#7919;ng t&#7871; b&agrave;o &#273;&#7897;t bi&#7871;n &#273;&#7875; thay th&#7871; nh&#7919;ng gen b&#7883; x&aacute;o tr&#7897;n b&#7857;ng nh&#7919;ng gen kh&#7887;e m&#7841;nh, v&igrave; c&aacute;c protein n&agrave;y ch&#7881; c&oacute; th&#7875; &#273;&#432;&#7907;c t&igrave;m th&#7845;y tr&ecirc;n c&aacute;c t&#7871; b&agrave;o b&#7845;t th&#432;&#7901;ng, nh&#432;ng vi&#7879;c n&agrave;y c&#7921;c k&#7923; kh&oacute; kh&#259;n v&agrave; &#7849;n ch&#7913;a nhi&#7873;u v&#7845;n &#273;&#7873; ph&#7913;c t&#7841;p. V&igrave; v&#7853;y li&#7879;u ph&aacute;p gen v&#7851;n c&ograve;n l&agrave; m&#7897;t gi&#7845;c m&#417; kh&ocirc;ng th&#7875; &aacute;p d&#7909;ng th&#7921;c t&#7871; trong t&#432;&#417;ng lai g&#7847;n.<\/p>\n<p>Th&#7853;t b&#7845;t ng&#7901;, m&#7897;t s&#7889; nh&agrave; khoa h&#7885;c g&#7847;n &#273;&acirc;y &#273;&atilde; thay &#273;&#7893;i l&#7889;i t&#432; duy v&#7873; ho&#7841;t &#273;&#7897;ng &#273;i&#7873;u ch&#7881;nh t&#7871; b&agrave;o. Sau khi k&#7871;t h&#7907;p c&ocirc;ng ngh&#7879; cao v&#7899;i c&aacute;c ph&#432;&#417;ng ph&aacute;p tu luy&#7879;n truy&#7873;n th&#7889;ng, c&oacute; &iacute;t nh&#7845;t m&#7897;t nh&oacute;m nghi&ecirc;n c&#7913;u, d&#7851;n &#273;&#7847;u b&#7903;i Ti&#7871;n s&#297; Lili Feng thu&#7897;c Ph&ograve;ng Y t&#7871; c&#7911;a Tr&#432;&#7901;ng &#272;&#7841;i h&#7885;c Y Baylor &#7903; Houston, &#273;&atilde; ph&aacute;t hi&#7879;n ra nhi&#7873;u s&#7921; kh&aacute;c bi&#7879;t r&otilde; r&agrave;ng gi&#7919;a nh&#7919;ng ng&#432;&#7901;i tu luy&#7879;n <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a> v&agrave; nh&#7919;ng ng&#432;&#7901;i kh&ocirc;ng luy&#7879;n c&ocirc;ng trong bi&#7875;u th&#7913;c gen &#7903; c&aacute;c b&#7841;ch c&#7847;u trung t&iacute;nh. B&#7841;ch c&#7847;u trung t&iacute;nh (neutrophils) l&agrave; nh&#7919;ng t&#7871; b&agrave;o m&aacute;u m&agrave;u tr&#7855;ng &#273;&oacute;ng vai tr&ograve; ch&#7911; &#273;&#7841;o trong vi&#7879;c ng&#259;n ng&#7915;a vi khu&#7849;n x&acirc;m nh&#7853;p.<\/p>\n<p>C&aacute;c nh&agrave; khoa h&#7885;c n&agrave;y &#273;&atilde; d&ugrave;ng c&ocirc;ng ngh&#7879; gene-chip &#273;&#7875; &#273;&#7889;i chi&#7871;u bi&#7875;u th&#7913;c c&#7911;a 12.000 gen trong c&aacute;c b&#7841;ch c&#7847;u trung t&iacute;nh c&#7911;a nh&#7919;ng ng&#432;&#7901;i luy&#7879;n c&ocirc;ng v&agrave; nh&#7919;ng ng&#432;&#7901;i kh&ocirc;ng luy&#7879;n c&ocirc;ng. H&#7885; &#273;&atilde; t&igrave;m th&#7845;y c&aacute;c bi&#7875;u th&#7913;c kh&aacute;c bi&#7879;t &#7903; h&#417;n 300 gen, trong &#273;&oacute; s&#7921; ch&ecirc;nh l&#7879;ch g&#7845;p kho&#7843;ng 10 l&#7847;n ho&#7863;c h&#417;n. &#272;&acirc;y l&agrave; m&#7897;t hi&#7879;n t&#432;&#7907;ng hy h&#7919;u trong ng&agrave;nh nghi&ecirc;n c&#7913;u sinh h&#7885;c t&#7871; b&agrave;o. V&iacute; d&#7909;, ch&uacute;ng ta &#273;&#7873;u bi&#7871;t r&#7857;ng c&aacute;c t&#7871; b&agrave;o b&igrave;nh th&#432;&#7901;ng v&agrave; t&#7871; b&agrave;o ung th&#432; r&#7845;t kh&aacute;c nhau, b&#7903;i v&igrave; DNA hay b&#7897; gen s&#7869; b&#7883; ph&acirc;n chia qu&aacute; nhi&#7873;u l&#7847;n trong c&aacute;c t&#7871; b&agrave;o kh&#7889;i u.<\/p>\n<p>Trong qu&aacute; tr&igrave;nh kh&#7843;o s&aacute;t, c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u ph&aacute;t hi&#7879;n ra r&#7857;ng s&#7889; l&#432;&#7907;ng b&#7841;ch c&#7847;u trung t&iacute;nh trong m&#7851;u gen c&#7911;a c&aacute;c h&#7885;c vi&ecirc;n <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a> b&#7883; gi&#7843;m xu&#7889;ng. Ngo&agrave;i ra, tu&#7893;i th&#7885; c&#7911;a b&#7841;ch c&#7847;u trung t&iacute;nh c&#7911;a ng&#432;&#7901;i kh&#7887;e m&#7841;nh b&igrave;nh th&#432;&#7901;ng ch&#7881; c&oacute; t&#7915; 2-3 ti&#7871;ng, nh&#432;ng l&#7841;i k&eacute;o d&agrave;i 60 ti&#7871;ng &#273;&#7889;i v&#7899;i c&aacute;c h&#7885;c vi&ecirc;n <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a>. H&#7885; c&#361;ng quan s&aacute;t &#273;&#432;&#7907;c r&#7857;ng b&#7841;ch c&#7847;u trung t&iacute;nh c&#7911;a ng&#432;&#7901;i luy&#7879;n c&ocirc;ng &#273;&#432;&#7907;c ph&acirc;n t&aacute;ch to&agrave;n di&#7879;n h&#417;n, kh&ocirc;ng gi&#7889;ng nh&#432; ng&#432;&#7901;i b&igrave;nh th&#432;&#7901;ng c&oacute; b&#7841;ch c&#7847;u trung t&iacute;nh b&#7883; tri&#7879;t ti&ecirc;u tr&#432;&#7899;c khi k&#7871;t th&uacute;c qu&aacute; tr&igrave;nh ph&acirc;n t&aacute;ch, c&#361;ng gi&#7889;ng nh&#432; m&#7897;t ng&#432;&#7901;i &#273;&#7897;t nhi&ecirc;n ch&#7871;t tr&#432;&#7899;c khi h&#7871;t tu&#7893;i th&#7885;. Trong khi &#273;&oacute; b&#7841;ch c&#7847;u trung t&iacute;nh c&#7911;a ng&#432;&#7901;i luy&#7879;n c&ocirc;ng l&#7841;i s&#7889;ng h&#7871;t th&#7901;i gian &#273;&atilde; &#273;&#7883;nh. T&#7915; nh&#7919;ng kh&aacute;m ph&aacute; n&agrave;y, ch&uacute;ng ta c&oacute; th&#7875; ph&#7887;ng &#273;o&aacute;n r&#7857;ng s&#7889; l&#432;&#7907;ng &iacute;t b&#7841;ch c&#7847;u trung t&iacute;nh trong c&#417; th&#7875; c&aacute;c h&#7885;c vi&ecirc;n <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a> c&oacute; th&#7875; kh&#7903;i t&aacute;c d&#7909;ng ng&#259;n ng&#7915;a s&#7921; l&acirc;y nhi&#7877;m t&#7915; b&ecirc;n ngo&agrave;i hi&#7879;u qu&#7843; h&#417;n b&#7903;i v&igrave; ch&uacute;ng c&oacute; tu&#7893;i th&#7885; d&agrave;i h&#417;n. Do c&#417; th&#7875; h&#7885;c vi&ecirc;n <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a> kh&ocirc;ng c&#7847;n nhi&#7873;u b&#7841;ch c&#7847;u trung t&iacute;nh, n&ecirc;n s&#7889; l&#7847;n k&iacute;ch ho&#7841;t v&agrave; t&aacute;i k&iacute;ch ho&#7841;t h&#7879; &#273;i&#7873;u ti&#7871;t globulin mi&#7877;n d&#7883;ch c&oacute; th&#7875; kh&ocirc;ng nhi&#7873;u b&#7857;ng nh&#7919;ng ng&#432;&#7901;i kh&ocirc;ng luy&#7879;n c&ocirc;ng. Nh&#7901; &#273;&oacute;, c&aacute;c h&#7885;c vi&ecirc;n <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a> s&#7869; kh&ocirc;ng &#273;&#7889;i m&#7863;t v&#7899;i nguy c&#417; cao b&#7883; d&#7883; &#7913;ng, hen suy&#7877;n, b&#7879;nh t&#7921; mi&#7877;n d&#7883;ch, ho&#7863;c c&aacute;c ch&#7913;ng r&#7889;i lo&#7841;n mi&#7877;n d&#7883;ch qua trung gian kh&aacute;c.<\/p>\n<p>Nh&#7919;ng con &#273;&#432;&#7901;ng r&#7907;p b&oacute;ng c&acirc;y ng&agrave;y nay &#273;ang d&#7847;n bi&#7871;n m&#7845;t do vi&#7879;c &#7891; &#7841;t x&acirc;y d&#7921;ng c&aacute;c c&aacute;c nh&agrave; m&aacute;y v&agrave; &#273;&#432;&#7901;ng x&aacute; &#273;&#7875; gi&#7843;m t&#7843;i v&#7845;n &#273;&#7873; t&#7855;c ngh&#7869;n giao th&ocirc;ng &#273;ang di&#7877;n bi&#7871;n ng&agrave;y c&agrave;ng nghi&ecirc;m tr&#7885;ng, v&agrave; do nh&#7919;ng h&#7853;u qu&#7843; kh&aacute;c c&#7911;a s&#7921; &#273;&ocirc; th&#7883; h&oacute;a. S&#7921; thay &#273;&#7893;i m&ocirc;i tr&#432;&#7901;ng s&#7889;ng thu&#7897;c lo&#7841;i n&agrave;y khi&#7871;n cho h&#7879; mi&#7877;n d&#7883;ch c&#7911;a con ng&#432;&#7901;i kh&ocirc;ng ng&#7915;ng b&#7883; k&iacute;ch th&iacute;ch b&#7903;i b&#7909;i b&#7863;m v&agrave; d&#7877; d&agrave;ng d&#7851;n &#273;&#7871;n c&aacute;c ch&#7913;ng d&#7883; &#7913;ng. Th&#7853;t v&#7853;y, r&#7845;t nhi&#7873;u tr&#7867; em ph&#7843;i &#273;&#7871;n b&#7879;nh vi&#7879;n do d&#7883; &#7913;ng. Th&#7871; nh&#432;ng c&aacute;c b&aacute;c s&#297; nh&#7853;n th&#7845;y r&#7857;ng r&#7845;t kh&oacute; &#273;&#7875; ch&#7919;a tr&#7883; d&#7913;t &#273;i&#7875;m c&aacute;c ch&#7913;ng d&#7883; &#7913;ng b&#7857;ng b&#7845;t k&#7875; lo&#7841;i thu&#7889;c n&agrave;o &#273;ang c&oacute; tr&ecirc;n th&#7883; tr&#432;&#7901;ng.<\/p>\n<p>C&aacute;ch duy nh&#7845;t &#273;&#7875; gi&#7843;i ph&oacute;ng kh&#7887;i c&aacute;c b&#7879;nh t&#7853;t l&agrave; ph&#7843;i t&#259;ng c&#432;&#7901;ng h&#7879; mi&#7877;n d&#7883;ch c&#7911;a con ng&#432;&#7901;i &#273;&#7875; n&oacute; c&oacute; th&#7875; th&#7853;t s&#7921; ch&#7889;ng ch&#7885;i l&#7841;i s&#7921; x&acirc;m nh&#7853;p c&#7911;a vi khu&#7849;n. C&aacute;c nh&agrave; khoa h&#7885;c c&oacute; t&#432; t&#432;&#7903;ng c&#7845;p ti&#7871;n n&agrave;y &#273;&atilde; ph&aacute;t hi&#7879;n ra r&#7857;ng tu luy&#7879;n <a href=\"http:\/\/phapluan.org\/\">Ph&aacute;p Lu&acirc;n &#272;&#7841;i Ph&aacute;p<\/a> l&agrave; m&#7897;t ph&#432;&#417;ng ph&aacute;p hi&#7879;u qu&#7843; &#273;&#7875; t&#259;ng c&#432;&#7901;ng h&#7879; mi&#7877;n d&#7883;ch. Ng&agrave;y nay, r&#7845;t d&#7877; t&igrave;m th&#7845;y nh&#7919;ng <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#diem_luyen_cong\" 28726 rel=\"nofollow\" target=\"_blank\">&#273;i&#7875;m luy&#7879;n c&ocirc;ng<\/a> tr&ecirc;n kh&#7855;p th&#7871; gi&#7899;i. V&#7853;y t&#7841;i sao c&aacute;c b&#7841;n c&ograve;n ch&#432;a th&#7917; t&#7853;p <a class=\"lar-automated-link\" href=\"https:\/\/chanhkien.org\/chu-giai-tu-vung#phap_luan_cong\" rel=\"nofollow\" target=\"_blank\">Ph&aacute;p Lu&acirc;n C&ocirc;ng<\/a>?<\/p>\n<p>Xem th&ecirc;m:<\/p>\n<p><a href=\"http:\/\/chanhkien.org\/2010\/07\/kiem-tra-mau-hoc-vien-phap-luan-dai-phap-khien-cac-chuyen-gia-kinh-ngac.html\">>>&nbsp; Ki&#7875;m tra m&aacute;u h&#7885;c vi&ecirc;n Ph&aacute;p Lu&acirc;n &#272;&#7841;i Ph&aacute;p khi&#7871;n c&aacute;c chuy&ecirc;n gia kinh ng&#7841;c<\/a><br>\n<a href=\"http:\/\/chanhkien.org\/2014\/02\/tu-luyen-co-the-san-sinh-nang-luong-sieu-thuong.html\">>>&nbsp; Tu luy&#7879;n c&oacute; th&#7875; s&#7843;n sinh n&#259;ng l&#432;&#7907;ng si&ecirc;u th&#432;&#7901;ng<\/a><\/p>\n<p>D&#7883;ch t&#7915;:<\/p>\n<p><a href=\"http:\/\/pureinsight.org\/node\/197\">http:\/\/pureinsight.org\/node\/197<\/a><\/p>\n\n\n\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1ch duy nh\u1ea5t \u0111\u1ec3 gi\u1ea3i ph\u00f3ng kh\u1ecfi c\u00e1c b\u1ec7nh t\u1eadt l\u00e0 ph\u1ea3i t\u0103ng c\u01b0\u1eddng h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a con ng\u01b0\u1eddi \u0111\u1ec3 n\u00f3 c\u00f3 th\u1ec3 th\u1eadt s\u1ef1 ch\u1ed1ng ch\u1ecdi l\u1ea1i s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a vi khu\u1ea9n. <\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","ngg_post_thumbnail":0,"footnotes":""},"categories":[80],"tags":[],"class_list":["post-23386","post","type-post","status-publish","format-standard","hentry","category-khoa-hoc-khac"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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